CD125; interleukin-5 receptor subunit alpha; IL-5R-alpha; CDw125; CD125 (IL5RA, IL5R)
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Function
- low affinity IL-5 receptor
- GM-CSF receptor, IL-3 receptor, & IL-5 receptor share a common beta subunit, KH97
Structure
- the WSXWS motif appears to be necessary for proper proteinfolding, efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 5 subfamily
Compartment
membrane
Alternative splicing
named isoforms=3
Expression
expressed on eosinophils & basophils
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q01344.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il5ra/
- ↑ Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992 Mar 13;255(5050):1434-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1542794
- ↑ Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470