CDw131; cytokine receptor common subunit beta; KH97; GM-CSF/IL-3/IL-5 receptor common beta-chain; CDw131; CD131 (CSF2RB, IL3RB, IL5RB)

Function

• beta subunit is common to
  • IL3 receptor
  • IL5 receptor
  • GM-CSF receptors (IL3R, IL5R &
• associates with:
  • IL-3 receptor alpha
  • IL-5 receptor alpha
  • GM-CSF receptor alpha

Structure

• the WSXWS motif appears to be necessary for proper protein folding & thereby efficient intracellular transport & cell-surface receptor binding
• the box 1 motif is required for JAK interaction &/or activation
• belongs to the type 1 cytokine receptor family, type 4 subfamily
• contains 2 fibronectin F3 modules

Compartment

membrane

Alternative splicing

named isoforms=2

Pathology

• defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis

More general terms

• CD antigen
• cytokine receptor
• oligomerizing protein
• glycoprotein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1439
• OMIM: https://mirror.omim.org/entry/138981
• OMIM: https://mirror.omim.org/entry/265120
• UniProt: http://www.uniprot.org/uniprot/P32927.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1439