CD123; interleukin-3 receptor subunit alpha; IL-3R-alpha (IL3RA, IL3R)
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Function
- subunit of interleukin-3 receptor (heterodimer)
- low affinity IL-3 receptor
- CSF2RB required for high-affinity receptor
- associates with/caveolates lyn[6]
Structure
- the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 5 subfamily
Compartment
membrane
Notes
- the gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X & Y chromosomes
More general terms
Additional terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P26951.html
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/IL3RAID40959chXp22Yp13.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il3ra/
- ↑ Itoh N, Yonehara S, Schreurs J, Gorman DM, Maruyama K, Ishii A, Yahara I, Arai K, Miyajima A. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science. 1990 Jan 19;247(4940):324-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2404337
- ↑ Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992 Mar 13;255(5050):1434-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1542794
- ↑ 6.0 6.1 Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1281458