CDw116; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GM-CSF receptor-alpha; GM-CSF-R-alpha; GMR;CD116 (CSF2RA, CSF2R, CSF2RY)

Function

• low affinity receptor for GM-CSF
• combines with KH97 to from GM-CSF receptor
• transduces a signal that results in the proliferation, differentiation, & functional activation of hematopoietic cells
• associates with/activates lyn & yes

Structure

• the WSXWS motif appears to be necessary for proper protein folding, intracellular transport & cell- surface receptor binding
• the box 1 motif is required for JAK interaction &/or activation
• belongs to the type I cytokine receptor family, type 5 subfamily

Compartment

• cell membrane -isoforms 3,4,6 secreted (probable)

Alternative splicing

named isoforms=6

Expression

• monocytes
• neutrophils
• eosinophils
• fibroblasts
• endothelial cells
• dendritic cells

Pharmacology

• mavrilimumab is a GM-CSF receptor-alpha antagonist under investigational use for treatment of rheumatoid arthritis & hyper inflammatory ?COVID-19

Notes

• the gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X & Y chromosomes

More general terms

• hematopoietin receptor superfamily
• colony-stimulating factor [CSF] receptor
• CD antigen

Additional terms

• granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF)

Component of

• granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor or colony stimulating factor receptor 2

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1438
• OMIM: https://mirror.omim.org/entry/306250
• OMIM: https://mirror.omim.org/entry/425000
• UniProt: http://www.uniprot.org/uniprot/P15509.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1438