Opioid Overdose

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Etiology

Epidemiology

Clinical manifestations

Adverse effects

Drug interactions

Differential diagnosis

Management

More general terms

Additional terms

References

  1. 1.0 1.1 Bohnert ASB et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA 2011 Apr 6; 305:1315. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21467284
  2. Centers for Disease Control & prevention Vital Signs: Overdoses of Prescription Opioid Pain Relievers --- United States, 1999--2008 MMWR November 4, 2011 / 60(43);1487-1492 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6043a4.htm
  3. 3.0 3.1 3.2 Medical Knowledge Self Assessment Program (MKSAP) 16, 18, 19. American College of Physicians, Philadelphia 2012, 2018, 2022.
  4. 4.0 4.1 Dahan A, Aarts L, Smith TW. Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression. Anesthesiology. 2010 Jan;112(1):226-38 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20010421
  5. Centers for Disease Control and Prevention Vital Signs: Overdoses of Prescription Opioid Pain Relievers and Other Drugs Among Women - United States, 1999-2010 MMWR. July 5, 2013 / 62(26);537-542 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6226a3.htm
  6. 6.0 6.1 FDA News Release: April 3, 2014 FDA approves new hand-held auto-injector to reverse opioid overdose. First naloxone treatment specifically designed to be given by family members or caregivers. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm391465.htm
  7. Jones CM et al Alcohol Involvement in Opioid Pain Reliever and Benzodiazepine Drug Abuse-Related Emergency Department Visits and Drug- Related Deaths - United States, 2010 MMWR. October 10, 2014 / 63(40);881-885 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6340a1.htm
  8. 8.0 8.1 World Health Organization. 2014 Community Management of opioid overdose http://apps.who.int/iris/bitstream/10665/137462/1/9789241548816_eng.pdf?ua=1
  9. 9.0 9.1 Wheeler E et al Opioid Overdose Prevention Programs Providing Naloxone to Laypersons - United States, 2014 MMWR Weekly. June 19, 2015 / 64(23);631-635 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6423a2.htm
  10. 10.0 10.1 Rudd RA, Aleshire N, Zibbell JE, Gladden RM Increases in Drug and Opioid Overdose Deaths - United States, 2000-2014. MMWR. December 18, 2015 / 64(Early Release);1-5 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm64e1218a1.htm
    CDC Press Release. Dec 18, 2015 Drug overdose deaths hit record numbers in 2014 http://www.cdc.gov/media/releases/2015/p1218-drug-overdose.html
  11. 11.0 11.1 Larochelle MR et al Opioid Prescribing After Nonfatal Overdose and Association With Repeated Overdose: A Cohort Study. Ann Intern Med. Published online 29 December 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26720742 <Internet> http://annals.org/article.aspx?articleid=2479117
    Gregg J Follow-up to Nonfatal Opioid Overdoses: More of the Same or an Opportunity for Change? Ann Intern Med. Published online 29 December 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26720852 <Internet> http://annals.org/article.aspx?articleid=2479118
  12. 12.0 12.1 12.2 Jones CM, Baldwin GT, Manocchio T, White JO, Mack KA Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014. MMWR Morb Mortal Wkly Rep 2016;65:667-671 https://www.cdc.gov/mmwr/volumes/65/wr/mm6526a2.htm
  13. 13.0 13.1 13.2 Gaither JR, Leventhal JM, Ryan SA et al National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012. JAMA Pediatr. Published online October 31, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27802492 <Internet> http://jamanetwork.com/journals/jamapediatrics/fullarticle/2571466
  14. 14.0 14.1 14.2 Rudd RA, Seth P, David F, Scholl L. Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015. MMWR Morb Mortal Wkly Rep. ePub: 16 December 2016. https://www.cdc.gov/mmwr/volumes/65/wr/mm655051e1.htm
  15. 15.0 15.1 15.2 Hedegaard H, Warner M, Minino AM Drug Overdose Deaths in the United States, 1999-2015 NCHS Data Brief. No 273. Feb 2017 https://www.cdc.gov/nchs/data/databriefs/db273.pdf
  16. 16.0 16.1 16.2 Sun EC, Dixit A, Humphreys K et al Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis. BMJ 2017;356:j760 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28292769 Free full text <Internet> http://www.bmj.com/content/356/bmj.j760
    Karaca-Mandic P, Meara E, Morden NE. The growing problem of co-treatment with opioids and benzodiazepines. BMJ 2017;356:j1224 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28292825 Free full text <Internet> http://www.bmj.com/content/356/bmj.j1224
  17. 17.0 17.1 17.2 Somerville NJ, O'Donnell J, Gladden RM, et al. Characteristics of Fentanyl Overdose - Massachusetts, 2014-2016. MMWR Morb Mortal Wkly Rep 2017;66:382-386 https://www.cdc.gov/mmwr/volumes/66/wr/mm6614a2.htm
  18. 18.0 18.1 18.2 18.3 O'Donnell JK, Halpin J, Mattson CL, Goldberger BA, Gladden RM. Deaths Involving Fentanyl, Fentanyl Analogs, and U-47700 - 10 States, July-December 2016. MMWR Morb Mortal Wkly Rep. ePub: 27 October 2017 https://www.cdc.gov/mmwr/volumes/66/wr/mm6643e1.htm
  19. 19.0 19.1 19.2 Chou R, Korthuis PT, McCarty D et al Management of Suspected Opioid Overdose With Naloxone in Out-of-Hospital Settings: A Systematic Review. Ann Intern Med. 2017. Nov 28. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29181532 <Internet> http://annals.org/aim/fullarticle/2664376/management-suspected-opioid-overdose-naloxone-out-hospital-settings-systematic-review
    Oliva EM, Bounthavong M. Emergency Medical Services Naloxone Administration: Many Unknowns and Opportunities. Ann Intern Med. 2017. Nov 28. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29181541 <Internet> http://annals.org/aim/article-abstract/2664377/emergency-medical-services-naloxone-administration-many-unknowns-opportunities
  20. 20.0 20.1 Song Z Mortality Quadrupled Among Opioid-Driven Hospitalizations, Notably Within Lower-Income And Disabled White Population. Health Affairs. Dec 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29200349 https://www.healthaffairs.org/doi/10.1377/hlthaff.2017.0689
  21. 21.0 21.1 21.2 Vivolo-Kantor AM, Seth P, Gladden RM et al. Trends in Emergency Department Visits for Suspected Opioid Overdoses - United States, July 2016-September 2017. MMWR Morb Mortal Wkly Rep. ePub: 6 March 2018. https://www.cdc.gov/mmwr/volumes/67/wr/mm6709e1.htm
  22. 22.0 22.1 Brooks M Surgeon General Urges More Americans to Carry Overdose Antidote. Medscape - Apr 05, 2018. https://www.medscape.com/viewarticle/894837
    Adams JM Increasing Naloxone Awareness and Use. The Role of Health Care Practitioners. JAMA. Published online April 5, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29621389 https://jamanetwork.com/journals/jama/fullarticle/2678206
    U.S. Dept of Health & Human Services. Surgeon General's Advisory on Naloxone and Opioid Overdose. https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/naloxone-advisory.html
  23. 23.0 23.1 23.2 Jones CM, Einstein EB, Compton WM et al Changes in Synthetic Opioid Involvement in Drug Overdose Deaths in the United States, 2010-2016. JAMA. 2018;319(17):1819-1821. May 1, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29715347 https://jamanetwork.com/journals/jama/fullarticle/2679931
  24. 24.0 24.1 Fink DS, Schleimer JP, Sarvet A et al. Association between prescription drug monitoring programs and nonfatal and fatal drug overdoses: A systematic review. Ann Intern Med 2018 May 8; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29801093 <Internet> http://annals.org/aim/article-abstract/2680723/association-between-prescription-drug-monitoring-programs-nonfatal-fatal-drug-overdoses
    Compton WM, Wargo EM. Prescription drug monitoring programs: Promising practices in need of refinement. Ann Intern Med 2018 May 8 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29801101 <Internet> http://annals.org/aim/article-abstract/2680724/prescription-drug-monitoring-programs-promising-practices-need-refinement
  25. 25.0 25.1 25.2 Gomes T, Tadrous M, Mamdani MM et al The Burden of Opioid-Related Mortality in the United States. JAMA Network Open. 2018;1(2):e180217. Not indexed in PubMed https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2682878
  26. NEJM Knowledge+ Question of the Week. June 5, 2018 https://knowledgeplus.nejm.org/question-of-week/1826/
  27. Boyer EW. Management of opioid analgesic overdose. N Engl J Med 2012 Jul 12; 367:146 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22784117 Free PMC Article https://www.nejm.org/doi/full/10.1056/NEJMra1202561
  28. 28.0 28.1 Larochelle MR, Bernson D, Land T et al Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study. Ann Intern Med. 2018. June 19. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29913516 <Internet> http://annals.org/aim/article-abstract/2684924/medication-opioid-use-disorder-after-nonfatal-opioid-overdose-association-mortality
    Volkow ND, Wargo EM Overdose Prevention Through Medical Treatment of Opioid Use Disorders. Ann Intern Med. 2018. June 19 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29913514 <Internet> http://annals.org/aim/article-abstract/2684925/overdose-prevention-through-medical-treatment-opioid-use-disorders
  29. 29.0 29.1 29.2 Olfson M, Crystal S, Wall M et al Causes of Death After Nonfatal Opioid Overdose. JAMA Psychiatry. Published online June 20, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29926090 https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2685326
  30. 30.0 30.1 Centers for Disease Control & Prevention (CDC) Rising Numbers of Deaths Involving Fentanyl and Fentanyl Analogs, Including Carfentanil, and Increased Usage and Mixing with Non-opioids Emergency Preparedness and Response. July 11, 2018 https://emergency.cdc.gov/han/han00413.asp
    O'Donnell J, Gladden RM, Mattson CL, Kariisa M. Notes from the Field: Overdose Deaths with Carfentanil and Other Fentanyl Analogs Detected - 10 States, July 2016 - June 2017. MMWR Morb Mortal Wkly Rep 2018;67:767-768 https://www.cdc.gov/mmwr/volumes/67/wr/mm6727a4.htm
  31. 31.0 31.1 31.2 Carico R, Zhao X, Thorpe CT et al. Receipt of overlapping opioid and benzodiazepine prescriptions among veterans dually enrolled in Medicare Part D and the Department of Veterans Affairs: A cross-sectional study. Ann Intern Med 2018 Oct 9; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/30304353
  32. Gomes T et al. Contributions of prescribed and non-prescribed opioids to opioid related deaths: Population based cohort study in Ontario, Canada. BMJ 2018 Aug 29; 362:k3207. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30158106 Free PMC Article https://www.bmj.com/content/362/bmj.k3207
    Hadland SE, Kertesz SG. Opioid deaths in Ontario, Canada: Curbs to prescribing must be part of a broader package of measures. BMJ 2018 Aug 29; 362:k3537 PMID: https://www.ncbi.nlm.nih.gov/pubmed/3015825 https://www.bmj.com/content/362/bmj.k3537
  33. 33.0 33.1 Hadland SE, Rivera-Aguirre A, Marshall BDL et al. Association of pharmaceutical industry marketing of opioid products with mortality from opioid-related overdoses. JAMA Netw Open 2019 Jan 18; 2:e186007. Not indexed in PubMed https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2720914
  34. Willman MW, Liss DB, Schwarz ES, Mullins ME. Do heroin overdose patients require observation after receiving naloxone? Clin Toxicol (Phila). 2017 Feb;55(2):81-87. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27849133
  35. Babu KM, Brent J, Juurlink DN. Prevention of opioid overdose. N Engl J Med 2019 Jun 6; 380:2246. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31167053 https://www.nejm.org/doi/full/10.1056/NEJMra1807054
  36. SAMHSA. Opioid Overdose Prevention Toolkit http://store.samhsa.gov/product/opioid-overdose-prevention-toolkit/all-new-products/sma13-4742
    SAMHSA. Opioid Overdose Toolkit. Information for Prescribers. http://store.samhsa.gov/shin/content//SMA13-4742/Toolkit_Prescribers.pdf
  37. 37.0 37.1 Chino F, Kamal A, Chino J et al Incidence of Opioid-Associated Deaths in Cancer Survivors in the United States, 2006-2016A Population Study of the Opioid Epidemic. JAMA Oncol. Published online May 7, 2020. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32379275 https://jamanetwork.com/journals/jamaoncology/fullarticle/2765326
    Mehta AK, Smith TJ Palliative Care for Patients With Cancer in the COVID-19 Era. JAMA Oncol. Published online May 7, 2020 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32379855 https://jamanetwork.com/journals/jamaoncology/fullarticle/2765828
  38. Adewumi AD et al. Prescribed dose of opioids and overdose: a systematic review and meta-analysis of unintentional prescription opioid overdose. CNS Drugs 2018 Feb; 32:101. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29498021
  39. 39.0 39.1 39.2 Centers for Disease Control & Prevention (CDC) Increase in Fatal Drug Overdoses Across the United States Driven by Synthetic Opioids Before and During the COVID-19 Pandemic. CDC Health Alert Network. Dec 17, 2020 https://emergency.cdc.gov/han/2020/han00438.asp
  40. 40.0 40.1 40.2 40.3 40.4 Dezfulian C et al. Opioid-associated out-of-hospital cardiac arrest: Distinctive clinical features and implications for health care and public responses: A scientific statement from the American Heart Association. Circulation 2021 Mar 8; [e-pub] PMID: https://www.ncbi.nlm.nih.gov/pubmed/33682423 https://www.ahajournals.org/doi/10.1161/CIR.0000000000000958
  41. 41.0 41.1 Yunusa I, Gagne JJ, Yoshida K et al Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors. JAMA Netw Open. 2022;5(2):e220194 PMID: https://www.ncbi.nlm.nih.gov/pubmed/3520131 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789401
  42. 42.0 42.1 Stobbe M Two Powerful Drugs Now Adding to US Overdose Crisis Medscape. Jan 28, 2022 https://www.medscape.com/viewarticle/967484
  43. 43.0 43.1 43.2 43.3 NEJM Knowledge+ Psychiatry
  44. 44.0 44.1 NEJM Knowledge+ Pain Management and Opioids: Recharge
  45. 45.0 45.1 The HEALing Communities Study Consortium. Community-based cluster-randomized trial to reduce opioid overdose deaths. N Engl J Med 2024 Jun 16 PMID: https://www.ncbi.nlm.nih.gov/pubmed/38884347 https://www.nejm.org/doi/10.1056/NEJMoa2401177

Patient information

opioid (fentanyl) overdose patient information