fenoprofen (Nalfon)
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Introduction
Tradename: Nalfon.
Dosage
200-600 mg PO TID/QID, max 3200 mg/day
Tabs: 200, 300, 600 mg.
Pharmacokinetics
- food decreases rate & extent of absorption
- metabolized in liver to form 4-hydroxyfenoprofen glucuronide & fenoprofen glucuronide
elimination via liver
1/2life = 2.5-3 hours
protein binding = 99 %
elimination by hemodialysis = -
elimination by peritoneal dialysis = -
Adverse effects
- gastrointestinal disturbance
- rash
- tinnitus
- confusion
- anorexia
- leukopenia & thrombocytopenia (rare)
- nephrotoxicity (uncommon)
- hepatotoxicity (uncommon)
Drug interactions
- coadministration of aspirin decreases fenoprofen concentrations
- probenecid may increase fenoprofen concentration
- fenoprofen may increase plasma levels of:
- drug interaction(s) of direct oral anticoagulants (DOAC) with NSAIDs
- drug interaction(s) of cholinesterase inhibitors with NSAIDs
- drug interaction(s) of lithium carbonate with NSAIDs
- drug interaction(s) of NSAIDs with oral contraceptive
- drug interaction(s) of NSAIDs with SSRIs
- drug interaction(s) of NSAIDs with antidepressants
- drug interaction(s) of aspirin with NSAIDs
- drug interaction(s) of apixaban with NSAIDs
- drug interaction(s) of warfarin with NSAIDs
- drug interaction(s) of NSAIDs with beta blockers
- drug interaction(s) of NSAIDs with ARBs
- drug interaction(s) of NSAIDs with aldosterone antagonis
- drug interaction(s) of NSAIDs with glucocorticoid
- drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
- drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
- drug interaction(s) of NSAIDs with ACE inhibitors
- drug interaction(s) of NSAIDs & antihypertensives
- drug interaction(s) of NSAIDs & loop diuretics
- drug interaction(s) of NSAIDs & aspirin
Laboratory
More general terms
- non-steroidal anti-inflammatory agent (NSAID)
- peroxisome proliferator; PPAR agonist; PPAR gamma agonist