peroxisome proliferator; PPAR agonist; PPAR gamma agonist
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Function
- large class of structurally dissimilar molecules, originally identified as inducers of both the size & number of peroxisomes in rat & mouse hepatocytes
- peroxisome proliferators bind to peroxisome proliferator activated receptors (PPAR)
- binding specificity with PPAR varies with perxisome proliferator
- most bind to PPAR-gamma
- only a few seem to bind PPAR-beta/delta
- chronic exposure causes an increased incidence of liver tumors in mice & rats
Pharmacology
- the PPAR gamma agonist pioglitazone causes fewer cancer stem cells to remain dormant, thereby rendering them more vulnerable to chemotherapy with imatinib[2]
More general terms
More specific terms
- 5,8,11,14-eicosatetraynoic acid
- fenoprofen (Nalfon)
- fibrate
- glitazar
- ibuprofen (Motrin, Advil, Nuprin, Rufen, NeoProfen, Caldolor)
- indomethacin (Indocin)
- lanifibranor
- pioglitazone (Actos)
- piroxicam (Feldene)
- rosiglitazone (Avandia)
- troglitazone (Rezulin)
Additional terms
References
- ↑ Corton et al Annu Rev Pharmacol Toxicol 40:491, 2000
- ↑ 2.0 2.1 Prost S et al. Erosion of the chronic myeloid leukaemia stem cell pool by PPAR-gamma agonists. Nature 2015 Sep 17; 525:380. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26331539
Holyoake T and Vetrie D.Cancer: Repositioned to kill stem cells. Nature 2015 Sep 17; 525:328 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26331538