peroxisome proliferator-activated receptor (PPAR)
Jump to navigation
Jump to search
Function
- activated by fatty acids & peroxisome proliferators
- binds to DNA as heterodimer with RXR
- activated PPAR-alpha/RXR:
- may compete other nuclear receptors for RXRE enhancer elements (improper fit may bind without activation)
- induce peroxisome proliferation
- induction of fatty acid metabolism
- like other nuclear hormone receptors, PPAR are also regulated by coactivators & corepressors, which act as bridging proteins between the receptors & the transcriptional apparatus.
- coactivators & corepressors differ for the different PPARs
- coactivators include:
* uncertain as to identity of these proteins
More general terms
More specific terms
- peroxisome proliferator-activated receptor alpha; PPAR-alpha; nuclear receptor subfamily 1 group C member 1 (PPARA, NR1C1, PPAR)
- peroxisome proliferator-activated receptor delta; PPAR-delta; PPAR-beta; nuclear receptor subfamily 1 group C member 2; nuclear hormone receptor 1; NUC1; NUCI (PPARD, NR1C2, PPARB)
- peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3 (PPARG, NR1C3)
Additional terms
- CREB-binding protein; CBP transcriptional coactivator (CREBBP, CBP)
- histone acetyltransferase p300; p300 HAT; E1A-associated protein p300 (EP300, P300)
- mediator of RNA polymerase II transcription subunit 1
- nuclear receptor coactivator 1; NCoA-1; steroid receptor coactivator 1; SRC-1; RIP160; protein Hin-2; renal carcinoma antigen NY-REN-52; class E basic helix-loop-helix protein 74; bHLHe74 (NCOA1, BHLHE74, SRC1)
- peroxisome
- peroxisome proliferator; PPAR agonist; PPAR gamma agonist
- retinoid X receptor (RXR)
- tuberin; tuberous sclerosis 2 protein (TSC2 TSC4)
References
- ↑ Green S. Nuclear hormone receptors. Promiscuous liaisons. Nature. 1993 Feb 18;361(6413):590-1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8382343
- ↑ Nebert DW. Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. Mol Endocrinol. 1991 Sep;5(9):1203-14. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1663211
- ↑ Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor- retinoid X receptor heterodimers. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8384714
- ↑ Corton JC, Anderson SP, Stauber A. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol. 2000;40:491-518. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10836145