nuclear receptor coactivator 4; NCoA-4; androgen receptor-associated protein of 70 kDa; androgen receptor coactivator 70 kD protein; 70 kD androgen receptor coactivator; 70 kD AR-activator; Ret-activating protein ELE1 (NCOA4, ARA70, ELE1, RFG)

Function

• enhances the androgen receptor transcriptional activity in prostate cancer cells
• ligand-independent coactivator of PPAR-gamma
• interacts with the androgen receptor & the retinoid X receptor (RXR) (ligand-dependent)

Alternative splicing

named isoforms=2

Expression

• widely expressed
• detected in adipose tissues & in different cell lines
• isoform beta is only expressed in testis

Pathology

• chromosomal inversion inv(10)(q11.2;q11.2) involving NCOA4 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]
• the inversion generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic & radiation-associated post-Chernobyl thyroid papillary carcinomas

More general terms

• nuclear (steroid) receptor coactivator (NRC, SRC, NCoA)
• phosphoprotein

Additional terms

• nuclear hormone receptor family

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8031
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8031
• OMIM: https://mirror.omim.org/entry/188550
• OMIM: https://mirror.omim.org/entry/601984
• UniProt: http://www.uniprot.org/uniprot/Q13772.html