C-type lectin domain family 4 member A; C-type lectin DDB27; C-type lectin superfamily member 6; dendritic cell immunoreceptor; lectin-like immunoreceptor (CLEC4A, CLECSF6, DCIR, LLIR, HDCGC13P)

Function

• may be involved in regulating immune reactivity
• may play a role in modulating dendritic cell differentiation &/or maturation
• may be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated Ca+2 mobilization & protein tyrosine phosphorylation
• may interact with PTPN6 via its ITIM motif

Structure

• contains 1 ITIM motif
• the phosphorylated ITIM motif can bind the SH2 domain of several SH2 domain-containing phosphatases
• contains 1 C-type lectin domain

Compartment

• membrane; single-pass type 2 membrane protein (probable)

Alternative splicing

named isoforms=4

Expression

• expressed in dendritic cells, myeloid cells, B-cells & HL-60 cells (at protein level)
• TNF alpha, IL-1 alpha, & LPS, down-regulate expression at the surface of neutrophils (at protein level)
• expressed preferentially in hematopoietic tissues
• expressed in peripheral blood leukocytes, neutrophils
• moderate expression in spleen, lymph node, & bone marrow
• very low expression in thymus
• expressed in Ag-presenting cells (dentritic cells, monocytes, macrophages & B-cells)
• expressed on granulocytes
• expression decreased in dentritic cells by signals inducing maturation (e.g. CD40 ligand, LPS, & TNF alpha)
• isoform 2 mRNA expression is up-regulated by agonists of neutrophils GM-CSF, IL-3, IL-4 & IL-13

More general terms

• C-type lectin superfamily

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50856
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50856
• OMIM: https://mirror.omim.org/entry/605306
• UniProt: http://www.uniprot.org/uniprot/Q9UMR7.html