TIR domain-containing adapter molecule 2 (TICAM-2, TRIF-related adapter molecule, Toll/interleukin-1 receptor domain-containing protein, Toll-like receptor adaptor protein 3, NF-kappa-B-activating protein 502, TICAM2, TIRAP3, TIRP, TRAM)

Function

• role in LPS-TLR4 signaling to regulate the MYD88- independent pathway during innate immune response to LPS
• involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, & IKBKB
• physically bridges TLR4 & TICAM1 & functionally transmits LPS-TRL4 signal to TICAM1
• phosphorylated by PKCE in response to LPS
• phosphorylation is essential for its function
• depleted from membrane upon phosphorylation
• myristoylatation required for membrane association which is critical for its ability to initiate efficient signaling
• interacts with TLR4, TICAM1, IRF3 & IRF7 in response to LPS
• interacts with IL1R1, IL1RAP, IRAK2, IRAK3 & TRAF6
• interacts with protein kinase-inactive mutants of IRAK1 & IRAK4

Structure

• homodimer.
• TIR domain mediates the interaction with TRAF6
• contains 1 TIR domain

Compartment

• cytoplasm, Golgi
• cell membrane
• localized to the plasma membrane as a result of myristoylation
• phosphorylation on Ser-16 leads to its depletion from the membrane

Expression

• expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, & pancreas

More general terms

• myristoylated protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608321
• UniProt: http://www.uniprot.org/uniprot/Q86XR7.html