E3 SUMO-protein ligase PIAS2; androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; Miz1; PIAS-NY protein; protein inhibitor of activated STAT x; protein inhibitor of activated STAT2 (PIAS2, PIASX)

Function

• SUMO-ligase E3
• stabilizes interaction between UBE2I & substrate
• SUMO-tethering factor
• transcriptional coregulator in
  • STAT pathway
  • p53 pathway
  • steroid hormone signaling pathway
• gene silencing
• binds to sumoylated ELK1 & enhances its transcriptional activity
• sumoylation appears to enhance the PIASX interactions
• binds SUMO1 & UBE2I
• interacts with JUN, MDM2, PARK7, TP53, TP73 isoform alpha, STAT4 following IL12 & IFN-alpha stimulation of T-cells, GTF2I, GTF2IRD1, DAB2, MSX2, ESR1, ESR2, NR3C1, PGR, AR, NCOA2
• binds to CDKN1A promoter

Compartment

nucleus, nuclear speckles

Alternative splicing

named isoforms=3

Expression

• expressed mainly in testis
• up-regulated transiently during myeloid differentiation in cells lines induced by phorbol ester or retinoic acid

More general terms

• ring finger protein
• SUMO ligase E3 (sentrin ligase E3)
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9063
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9063
• OMIM: https://mirror.omim.org/entry/603567
• UniProt: http://www.uniprot.org/uniprot/O75928.html