C-Jun-amino-terminal kinase-interacting protein 2; JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; mitogen-activated protein kinase 8-interacting protein 2 (MAPK8IP2, IB2, JIP2 PRKM8IPL)
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Function
- the JNK-interacting protein (JIP) group of scaffold proteins selectively mediate JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module
- JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells
- may function as a regulator of vesicle transport, through interactions with JNK-signaling components & motor proteins (putative)
- forms homo- or heterooligomeric complexes
- binds specific components of the JNK signaling pathway namely JNK, MAPKK7 & MLK2, MLK3 & DLK
- also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (apoER2)
- binds cytoplasmic tails of LRP1 & LRP2 (megalin)
- binds the TPR motif-containing C-terminal of kinesin light chain, Klc1; pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (putative)
- interacts with the cytoplasmic domain of APP (putative)
Structure
- belongs to the JIP scaffold family
- contains 1 PID domain
- contains 1 SH3 domain
Compartment
- cytoplasm
- accumulates in cell surface projections
Alternative splicing
named isoforms=4
Expression
- expressed mainly in the brain & pancreas, including insulin-secreting cells
- in the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe & the amygdala
- also expressed in fetal brain
- very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland & salivary gland