XIAP-associated factor 1 (BIRC4-binding protein, XAF1, BIRC4BP, XIAPAF1)

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Function

Structure

contains 1 TRAF-type Zn+2 finger

Compartment

Alternative splicing

named isoforms=7

Expression

Pathology

  • expression is frequently down-regulated in cancer cell lines

More general terms

References

  1. 1.0 1.1 UniProt http://www.uniprot.org/uniprot/Q6GPH4.html
  2. 2.0 2.1 Xia Y, Novak R, Lewis J, Duckett CS, Phillips AC. Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. Mol Cell Biochem. 2006 Jun;286(1-2):67-76. Epub 2006 Jan 24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16432762
  3. 3.0 3.1 Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG. Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. Nat Cell Biol. 2001 Feb;3(2):128-33. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11175744

Database