NADH dehydrogenase B16.6 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, complex 1-B16.6, C1-B16.6, gene associated with retinoic-interferon-induced mortality 19 protein, GRIM-19, cell death-regulatory protein, CGI-39, CDA016, NDUFA13)

Function

• accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex 1)
• not involved in catalysis
• involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death; this apoptotic activity is inhibited by interaction with viral IRF1
• prevents the transactivation of STAT3 target genes
• may play a role in CARD15-mediated innate mucosal responses & serve to regulate intestinal epithelial cell responses to microbes
• interacts with CARD15, but not with CARD4
• interacts with STAT3, but not with STAT1, STAT2 & STAT5A
• interacts with HHV-8 IRF1, in the nucleus, with HPV-16 E6 & SV40 LT
• interacts with OLFM4

Structure

belongs to the complex 1 NDUFA13 subunit family

Compartment

• mitochondrial inner membrane, matrix side
• nucleus
• may be translocated into the nucleus upon IFN/RA treatment

Expression

• widely expressed
• highest expression in heart, skeletal muscle, liver, kidney & placenta
• in intestinal mucosa, down-regulated in areas involved in Crohn's disease & ulcerative colitis
• expressed in numerous fetal tissues
• induced by interferon beta combined with all-trans-retinoic acid

More general terms

• NADH dehydrogenase subunit

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P0J0.html