olfactomedin-4 (OLM4, G-CSF-stimulated clone 1 protein, hGC-1, hOLfD, antiapoptotic protein GW112, OLFM4, GW112, UNQ362/PRO698)

Function

• antiapoptotic factor
• promotes tumor growth
• promotes proliferation of pancreatic cancer cells by favoring transition from the S to G2/M phase
• facilitates cell adhesion
• interacts with NDUFA13
• interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin A & wheat germ agglutinin) & cadherin

Structure

• homomultimer, disulfide-linked, N-glycosylated
• olfactomedin-like domain is involved in the interaction with cadherin
• contains 1 olfactomedin-like domain

Compartment

• secreted, extracellular space
• may be found in mitochondrion & nucleus

Expression

• expressed during myeloid lineage development
• expressed in the prostate, small intestine & colon > bone marrow & stomach
• elevated expression during early S phase of cell cycle Paathology:
• highly expressed in pancreatic cancer tissues
• also expressed at high levels in stomach cancer & colon cancer

More general terms

• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6UX06.html