interferon regulatory factor 1 (IRF1)

Function

• specifically binds to the upstream regulatory region of type 1 IFN & IFN-inducible MHC class 1 genes (the interferon consensus sequence, ICS) & activates those genes

Structure

• belongs to the IRF family
• contains 1 tryptophan pentad repeat DNA-binding domain

Compartment

nucleus

Expression

induced by viruses & IFN

Pathology

• deletion or rearrangement of IRF1 are a cause of preleukemic myelodysplastic syndrome (MDS) & of acute myelogenous leukemia (AML)

More general terms

• interferon regulatory factor family

Database

• UniProt: http://www.uniprot.org/uniprot/P10914.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3659
• OMIM: https://mirror.omim.org/entry/147575
• OMIM: https://mirror.omim.org/entry/153550
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3659