morphea; localized cutaneous scleroderma; linear scleroderma

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Introduction

Cutaneous sclerosis, localized, linear or generalized, limited to the skin.

Classification

  • localized (circumscribed, solitary)
  • linear
  • generalized (pansclerotic)

Etiology

Epidemiology

  • onset between 20-50 years in 75%
  • linear morphea has earlier onset
  • pansclerotic morphea begins before age 14
  • female:male ratio 3:1

Pathology

* histopathology image[4]

Clinical manifestations

* images[4][5]

Laboratory

Diagnostic procedures

Complications

Differential diagnosis

Management

More general terms

References

  1. Color Atlas & Synopsis of Clinical Dermatology, Common & Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 274-77
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 177
  3. Jump up to: 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018.
  4. Jump up to: 4.0 4.1 4.2 Nguyen JV, Elston DM (images) Medscape: Morphea http://emedicine.medscape.com/article/1065782-overview
  5. Jump up to: 5.0 5.1 DermNet NZ. Morphoea (images) http://www.dermnetnz.org/immune/morphoea.html
  6. Tratenberg M, Gutwein F, Rao V, Sperber K, Wasserrman A, Ash J. Localized Scleroderma: A Clinical Review. Curr Rheumatol Rev. 2017;13(2):86-92. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27604889
  7. Gu A, Li J, Zhang LT Corrugated Indurated Short Cords on the Neck of a Teenage Girl. JAMA Dermatol. Published online April 14, 2021 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33851971 https://jamanetwork.com/journals/jamadermatology/fullarticle/2778394
  8. Jump up to: 8.0 8.1 8.2 Blaise M, Cardot-Leccia N, Seitz-Polski B et al Tocilizumab for Corticosteroid-Refractory Immune Checkpoint Inhibitor- Induced Generalized Morphea. JAMA Dermatol. Published online November 30, 2022. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36449277 https://jamanetwork.com/journals/jamadermatology/fullarticle/2798842

Patient information

morphea patient information