eosinophilia-myalgia syndrome (EMS)

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Introduction

Multisystemic inflammatory disorder with eosinophilia & myalgias.

Etiology

* It was found that one manufacturer supplied the majority of the L-tryptophan associated with EMS and there were certain changes and deficiencies in their manufacturing procedures.

Possible contaminants include 1,1'-ethylidenebis(tryptophan) and 3-(phenyl amino)alanine.

Clinical manifestations

Laboratory

Radiology

Differential diagnosis

Management

More general terms

Additional terms

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 783-84
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Das et al. Toxicology Letters 150:111-122, 2004