Herpes zoster (shingles) vaccine (Zostavax, Shingrix)

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Introduction

Tradenames:

Indications

* above

Contraindications

Benefit/risk

Dosage

* Shingrix also recommended (1 dose) after Zostvax[29][32]

Keep frozen (< -15 degrees C), reconstitute & use immediately. 19,400 plaque forming units per dose

Pharmacokinetics

Adverse effects

Drug interactions

Mechanism of action

Notes

More general terms

More specific terms

Additional terms

References

  1. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW Jr, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL; Shingles Prevention Study Group. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005 Jun 2;352(22):2271-84. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15930418
  2. 2.0 2.1 Prescriber's Letter 12(7): 2005 Vaccination for Herpes Zoster and Postherpetic Neuralgia Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210712&pb=PRL (subscription needed) http://www.prescribersletter.com
  3. Prescriber's Letter 13(7): 2006 Herpes Zoster (Zostavax) Vaccine Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220702&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. 4.0 4.1 Hornberger J and Robertus K Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. Ann Intern Med 2006, 145:317 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16954357
    Koplan JP & Harpaz R Shingles vaccine: Effective and costly or cost-effective? Ann Intern Med 2006, 145:386 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16954362
  5. Prescriber's Letter 13(12): 2006 Issues with Herpes Zoster (Zosatvax) Vaccine Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=221201&pb=PRL (subscription needed) http://www.prescribersletter.com http://www.cdc.gov/nip/publications/VIS/vis-shingles.pdf
  6. Kimberlin DW & Whitley RJ Varicella-zoster vaccine for the prevention of herpes zoster. N Engl J Med 2007, 356:1338 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17392303
    Chaves SS et al, Loss vaccine-induced immunity to varicella overtime. N Engl J Med 2007, 356:1121 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17360990
  7. Prescriber's Letter 15(1): 2008 Reimbursement for Medicare Part D-Covered Vaccines Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=240113&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. Harpaz R, Ortega-Sanchez IR, Seward JF; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008 Jun 6;57(RR-5):1-30; quiz CE2-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18528318
  9. Simberkoff MS et al Safety of herpes zoster vaccine in the shingles prevention study: A randomized trial. Ann Intern Med 2010 May 4; 152:545. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/20439572 <Internet> http://dx.doi.org/10.1059/0003-4819-152-9-201005040-00004
    Hurley LP et al. Barriers to the use of herpes zoster vaccine. Ann Intern Med 2010 May 4; 152:555. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/20439573 <Internet> http://dx.doi.org/10.1059/0003-4819-152-9-201005040-00005
    Donahue JG and Belongia EA. The looming rash of herpes zoster and the challenge of adult immunization. Ann Intern Med 2010 May 4; 152:609. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/20439578 <Internet> http://dx.doi.org/10.1059/0003-4819-152-9-201005040-00011
  10. 10.0 10.1 Tseng HF et al Herpes Zoster Vaccine in Older Adults and the Risk of Subsequent Herpes Zoster Disease JAMA. 2011;305(2):160-166 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21224457 <Internet> http://jama.ama-assn.org/content/305/2/160.short
  11. 11.0 11.1 11.2 FDA NEWS RELEASE: March 24, 2011 FDA approves Zostavax vaccine to prevent shingles in individuals 50 to 59 years of age http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm248390.htm
  12. 12.0 12.1 12.2 Prescriber's Letter 19(1): 2012 Lower Age Limit for Zostavax (Herpes Zoster Vaccine) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280118&pb=PRL (subscription needed) http://www.prescribersletter.com
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    Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016
    Medicare.gov Shingles shots https://www.medicare.gov/coverage/shingles-shots
  14. Schmader KE et al. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Clin Infect Dis 2012 Apr 1; 54:922. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22291101
    Li H-T et al. Herpes zoster vaccination in people aged 50-59 years. Clin Infect Dis 2012 Apr 1; 54:929. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22291101
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    Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
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  22. 22.0 22.1 Tseng HF et al. Vaccination against zoster remains effective in older adults who later undergo chemotherapy. Clin Infect Dis 2014 Oct 1; 59:913. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25097079 <Internet> http://cid.oxfordjournals.org/content/59/7/913
    Oxman MN and Schmader KE. Zoster vaccine in immunocompromised patients: Time to reconsider current recommendations. Clin Infect Dis 2014 Oct 1; 59:920. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25097080 <Internet> http://cid.oxfordjournals.org/content/59/7/920
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  25. 25.0 25.1 25.2 Le P, Rothberg MB Cost-Effectiveness of Herpes Zoster Vaccine for Persons Aged 50 Years. Ann Intern Med. Published online 8 September 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26344036 <Internet> http://annals.org/article.aspx?articleid=2434619
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  28. Centers for Disease Control and Prevention (CDC). Update on herpes zoster vaccine: licensure for persons aged 50 through 59 years. MMWR Morb Mortal Wkly Rep. 2011 Nov 11;60(44):1528. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22071592
  29. 29.0 29.1 29.2 29.3 29.4 29.5 29.6 NEJM JWatch Editors FDA Advisers Recommend Approval of New Shingles Vaccine. Physician's First Watch, Sept 14,2017 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
    GlaxoSmithKline. Oct 23, 2017 Shingrix approved in the US for prevention of shingles in adults aged 50 and over. Pooled clinical trial results showed > 90 percent efficacy across all age groups. https://www.gsk.com/en-gb/media/press-releases/shingrix-approved-in-the-us-for-prevention-of-shingles-in-adults-aged-50-and-over/
    Young K, Sadoughi S, Saitz R CDC Advisers Recommend New Herpes Zoster Vaccine over Zostavax. Physician's First Watch, Oct 23, 2017 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
    HIGHLIGHTS OF PRESCRIBING INFORMATION. SHINGRIX SHINGRIX (Zoster Vaccine Recombinant, Adjuvanted) Suspension for Intramuscular Injection https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Shingrix/pdf/SHINGRIX.PDF
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