oleocanthal (Hyeda)
Jump to navigation
Jump to search
Introduction
phenolic compound in extra virgin olive oil in amounts up to 200 ug/mL[4]
Indications
- transdermal olive oil formulation for relief of inflammation[2]
Adverse effects
- responsible for the burning sensation that occurs in the back of the throat when consuming extra virgin olive oil
Mechanism of action
- in vitro activity of 10-20 uM oleocanthal
- inhibits COX1 & COX2
- 9-10 mg of oleocanthal contains 10% of anti-inflammatory activity of 200-400 mg of ibuprofen[4]
- inhibits cell proliferation, cell migration, & invasion of breast cancer & prostate cancer cells via inhibition of c-Met
- inhibits AMPK in colon cancer cells
- inhibits macrophage inflammatory protein-1-alpha in multiple myeloma
- induces cell death of cancer cells in vitro
- induces both necrosis & apoptosis of cancer cells in vitro via induction of lysosomal membrane permeabilization
- cancer cells have fragile lysosomal membranes compared to non-cancerous cells
- in the absence of serum, oleocanthal induces necrosis of cancer cells (does not induce cleavage of caspase-3)
- induces both necrosis & apoptosis of cancer cells in vitro via induction of lysosomal membrane permeabilization
- suppresses proliferation of non-cancer cells by inhibiting Rb protein phosphorylation at Ser608
- normal cells resume proliferation 72 hours after oleocanthal treatment
- induces a reversible cell cycle arrest in non-cancerous cells that retain their viability
- inhibits acid sphingomyelinase which destabilizes the lysosomal membrane
- cancer cells overcome lysosomal membrane fragility by overexpression of HSP70 which enhances acid sphingomyelinase activity
More general terms
References
- ↑ LeGendre O, Breslin PA, Foster DA (-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization (LMP). Molecular & Cellular Oncology. 23 Jan 2015. http://dx.doi.org/10.1080/23723556.2015.1006077
- ↑ 2.0 2.1 PubChem: 16681728
- ↑ Wikipedia: Oleocanthal http://en.wikipedia.org/wiki/Oleocanthal
- ↑ 4.0 4.1 4.2 Beauchamp GK, Keast RSJ, Morel D et al Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil. Nature 437, 45-46 (1 September 2005) http://www.nature.com/nature/journal/v437/n7055/full/437045a.html
- ↑ Akl MR, Ayoub NM, Mohyeldin MM et al Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. PLoS One. 2014 May 21;9(5):e97622 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24849787