Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

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Epidemiology

  • Indiana patient transmitted MERS-CoV to Illinois man, but Illinois man not sick[12]
    • CDC concludes Indiana MERS patient did not spread MERS-CoV to Illinois business associate[12]
  • 2 workers at the Florida hospital treating the 2nd MERS-CoV case have developed flu-like symptoms % are being tested for MERS-CoV; 1 has been hospitalized[9]
  • neither of the two imported cases of MERS-CoV in the U.S. (2014) spread the virus to household members or health care workers who treated them[14]
  • 145 confirmed cases & 14 deaths in South Korea in May & June of 2015[18]

Pathology

Clinical manifestations

Laboratory

complete blood count

SaO2 low (91% case[23])

Radiology

Differential diagnosis

Management

More general terms

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Centers for Disease Control and Prevention Update: Severe Respiratory Illness Associated with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) - Worldwide, 2012-2013. MMWR Early Release June 7, 2013 / 62(Early Release);1-4 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm62e0607a1.htm
  2. ↑ Centers for Disease Control and Prevention Update, Case Definitions, and Guidance MERS Update http://www.cdc.gov/coronavirus/mers/case-def.html
  3. ↑ Assiri A et al Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus. N Engl J Med. June 19, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23782161 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1306742
  4. ↑ Centers for Disease Control and Prevention (CDC) Emergency Preparedness and Response. August 12, 2014 Notice to Healthcare Providers and Public Health Officials: Updated Guidance for the Evaluation of Severe Respiratory Illness Associated with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) http://emergency.cdc.gov/HAN/han00352.asp
  5. ↑ Centers for Disease Control and Prevention (CDC) Updated Information on the Epidemiology of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Guidance for the Public, Clinicians, and Public Health Authorities, 2012-2013 MMWR. September 27, 2013 / 62(38);793-796 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6238a4.htm
  6. ↑ 6.0 6.1 6.2 Centers for Disease Control and Prevention (CDC) CDC Newsroom. May 2, 2014 CDC announces first case of Middle East Respiratory Syndrome Coronavirus infection (MERS) in the United States. http://www.cdc.gov/media/releases/2014/p0502-US-MERS.html
    Centers for Disease Control and Prevention (CDC) CDC Newsroom. May 3, 2014 Confirmed Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Case in Indiana, 2014. http://emergency.cdc.gov/han/han00361.asp
  7. ↑ 7.0 7.1 Centers for Disease Control and Prevention (CDC) Press Release. Tuesday, May 12, 2014 CDC announces second imported case of Middle East Respiratory Syndrome (MERS) in the United States http://www.cdc.gov/media/releases/2014/p0512-US-MERS.html
  8. ↑ Centers for Disease Control and Prevention (CDC) Middle East Respiratory Syndrome (MERS) Interim Home Care and Isolation Guidance for MERS-CoV http://www.cdc.gov/coronavirus/mers/hcp/home-care.html
  9. ↑ 9.0 9.1 Young K MERS Update: 2 Florida Hospital Workers Have Flu-Like Illness, WHO Contemplates Calling a Public Health Emergency Physician's First Watch, May 14, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  10. ↑ 10.0 10.1 WHO Statement. May 14, 2014 WHO statement on the Fifth Meeting of the IHR Emergency Committee concerning MERS-CoV. http://www.who.int/mediacentre/news/statements/2014/mers-20140514/en/
  11. ↑ 11.0 11.1 Centers for Disease Control and Prevention (CDC) First Confirmed Cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in the United States, Updated Information on the Epidemiology of MERS-CoV Infection, and Guidance for the Public, Clinicians, and Public Health Authorities. MMWR. May 14, 2014 / 63(Early Release);1-6 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm63e0514a1.htm
  12. ↑ 12.0 12.1 12.2 Centers for Disease Control and Prevention (CDC) Press Release. May 17, 2014 Illinois resident who had contact with Indiana MERS patient tests positive for MERS coronavirus. http://www.cdc.gov/media/releases/2014/p0517-mers.html
    Centers for Disease Control and Prevention (CDC) Press Release. May 18, 2014 CDC concludes Indiana MERS patient did not spread virus to Illinois business associate. http://www.cdc.gov/media/releases/2014/p0528-mers.html
  13. ↑ 13.0 13.1 Azhar EI et al Evidence for Camel-to-Human Transmission of MERS Coronavirus. N Engl J Med. June 4, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24896817 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1401505
  14. ↑ 14.0 14.1 Centers for Disease Control and Prevention (CDC) Press Release. June 17, 2014 MERS-CoV not spread to household members or health care contacts of the two U.S. cases. http://www.cdc.gov/media/releases/2014/p0617-Mers.html
  15. ↑ Prescriber's Letter 21(7): 2014 COMMENTARY: MERS Clinical Features GUIDELINES: Interim Guidance for Health Professionals (MERS-CoV) (2014) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=300703&pb=PRL (subscription needed) http://www.prescribersletter.com
  16. ↑ 16.0 16.1 Drosten C et al. Transmission of MERS-coronavirus in household contacts. N Engl J Med 2014 Aug 28; 371:828 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25162889 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1405858
  17. ↑ 17.0 17.1 World Health Organization (WHO). Global Alert & Response (GAR) Disease outbreak news. June 6, 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) - Republic of Korea. http://www.who.int/csr/don/06-june-2015-mers-korea/en/
  18. ↑ 18.0 18.1 Centers for Disease Control and Prevention (CDC) Emergency Preparedness and Response. June 11, 2015 Updated Information and Guidelines for Evaluation of Patients for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection. http://emergency.cdc.gov/han/han00380.asp
    World Health Organization (WHO) News Release. June 13, 2015 WHO recommends continuation of strong disease control measures to bring MERS-CoV outbreak in Republic of Korea to an end. http://www.wpro.who.int/mediacentre/releases/2015/20150613/en/
  19. ↑ 19.0 19.1 NEJM JWatch editors South Korea Declares End to MERS-CoV Outbreak Physician's First Watch, July 29, 2015 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  20. ↑ Arabi YM, Arifi AA, Balkhy HH et al Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection. Ann Intern Med. 2014 Mar 18;160(6):389-97. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24474051
  21. ↑ 21.0 21.1 Hui DS, Memish ZA, Zumla A. Severe acute respiratory syndrome vs. the Middle East respiratory syndrome. Curr Opin Pulm Med. 2014 May;20(3):233-41. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24626235
  22. ↑ Sampathkumar P. Middle East respiratory syndrome: what clinicians need to know. Mayo Clin Proc. 2014 Aug;89(8):1153-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25034307
  23. ↑ 23.0 23.1 23.2 23.3 23.4 23.5 23.6 Medical Knowledge Self Assessment Program (MKSAP) 17, 18, American College of Physicians, Philadelphia 2015, 2018.
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