angiotensin converting enzyme 2 (ACE2)

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Kinetic parameters:



* high levels of expression

* expression upregulated by the farnesyl X receptor (FXR)[7]


More general terms

Additional terms


  1. OMIM
  2. 2.0 2.1 Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA et al Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003 Nov 27;426(6965):450-4. PMID:
  3. SeattleSNPs
  4. UniProt
  5. 5.0 5.1 Hoffmann M, Kleine-Weber H, Schroeder S SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. PMID:
  6. 6.0 6.1 Shi Z, de Vries HJ, Vlaar APJ et al Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers. JAMA Intern Med. Published online November 16, 2020. PMID: PMCID: PMC7670391 Free PMC article
  7. 7.0 7.1 Brevini T, Maes M, Webb GJ et al FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature 2022. Dec 5. PMID: