motilin; contains: motilin-associated peptide; MAP (MLN)

Function

• motilin is a stimulus for contraction of smooth muscle in the upper GI tract
• it increases motility of the gastric fundus & antrum, duodenum, & lower esophageal sphincter
• ingestion of fat stimulates, glucose inhibits, & protein has little effect on motilin release
• motilin's actions are most pronounced in the fasting state

Structure

belongs to the motilin family

Compartment

secreted

Expression

• motilin is secreted by cells in the small intestine, gall bladder & biliary tract & the pituitary & pineal gland

Pathology

• increases in motilin concentration have been observed in
  • Crohn's disease
  • ulcerative colitis
  • irritable bowel syndrome
  • tropical sprue
  • acute intestinal infection

More general terms

• secreted protein
• gastrointestinal hormone

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4295
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4295
• OMIM: https://mirror.omim.org/entry/158270
• UniProt: http://www.uniprot.org/uniprot/P12872.html