transmembrane protease serine 2; serine protease 10; contains: transmembrane protease serine 2 non-catalytic chain; transmembrane protease serine 2 catalytic chain (TMPRSS2, PRSS10)

Structure

• belongs to the peptidase S1 family
• contains 1 LDL-receptor class A domain
• contains 1 peptidase S1 domain
• contains 1 SRCR domain

Compartment

• cell membrane
• single-pass type 2 membrane protein
• transmembrane protease serine 2 catalytic chain: secreted
• activated by cleavage & secreted

Expression

• expressed strongly in small intestine
• also expressed in prostate, colon, stomach & salivary gland
• Expressed in type II pneumocytes in the lung

Pathology

• facilitates SARS CoV2 virus entry into cells after attachment of viral spike glycoprotein to ACE2 on the surface of human cells
• proteolytically cleaves & activates the viral spike glycoproteins which facilitate virus-cell membrane fusions
• fusion glycoproteins F0 of Sendai virus, metapneumovirus, parainfluenza 1, 2, 3, 4a & 4b viruses
• essential for spread & pathogenesis of influenza A virus (strains H1N1, H3N2, H7N9)
• role in proteolytic cleavage & activation of hemagglutinin (HA) protein

More general terms

• transmembrane serine protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7113
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7113
• OMIM: https://mirror.omim.org/entry/602060
• UniProt: http://www.uniprot.org/uniprot/O15393.html