influenza A H7N0 virus
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Epidemiology
- 131 confirmed cases in China as of 5/8/2013
- 32 deaths in China 2013[4]
- 120 cases 2016-2017 flu season in China[11]
- 460 cases of human infection with H7N9) reported in China October 2016 - February 2017[13]
- 60% of patients with known poultry exposure[4]
- no evidence of human to human transmission[6][10]
- evidence of human to human transmission reported[8]
- does not seem to cause symptoms in birds
Pathology
- etiologic agent of avian flu
- pneumonia
- septic shock
- brain damage
- multi-organ failure[2]
Clinical manifestations
- high fever
- cough
- dyspnea
- severe viral pneumonia
- rhabdomyolysis
- encephalopathy[3]
Laboratory
- influenza virus A serology
- influenza virus A H7 RNA
- influenza virus A H7 antigen
- influenza virus identified by culture
Complications
- high mortality (21%)
Management
- 5-day course of oseltamivir or inhaled zanamivir
- resistance to neuraminidase inhibitors is emerging[7]
More general terms
Additional terms
References
- ↑ Global Alert and Response World Health Organization H7N9 avian influenza human infections in China http://www.who.int/csr/don/2013_04_01/en/index.html
- ↑ 2.0 2.1 NBC News, April 12, 2013
- ↑ 3.0 3.1 Gao R et al Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus. N Engl J Med. April 16, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23577628 <Internet> http://www.nejm.org/doi/pdf/10.1056/NEJMoa1304459
Uyeki TM and Cox NJ Global Concerns Regarding Novel Influenza A (H7N9) Virus Infections. N Engl J Med. April 16, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23577629 <Internet> http://www.nejm.org/doi/pdf/10.1056/NEJMp1304661 - ↑ 4.0 4.1 4.2 Word Health Organization (WHO)
Human infection with avian influenza A(H7N9) virus in China - update. Global Alert and Response (GAR). April 17, 2013 http://www.who.int/csr/don/2013_04_17/en/index.html
Human infection with avian influenza A(H7N9) virus - update. Global Alert and Response (GAR). May 8, 2013 http://www.who.int/csr/don/2013_05_08/en/index.html - ↑ 5.0 5.1 Centers for Disease Control and Prevention (CDC) Interim Guidance on the Use of Antiviral Agents for Treatment of Human Infections with Avian Influenza A (H7N9). http://www.cdc.gov/flu/avianflu/h7n9-antiviral-treatment.htm
- ↑ 6.0 6.1 Li Q, Zhou L, Zhou M et al Preliminary Report: Epidemiology of the Avian Influenza A (H7N9) Outbreak in China. N Engl J Med. April 24, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23614499 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1304617
- ↑ 7.0 7.1 Hu Y et al Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. The Lancet. May 28, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23726392 <Internet> http://download.thelancet.com/flatcontentassets/pdfs/S0140673613611253.pdf
- ↑ 8.0 8.1 Zhou J et al. Biological features of novel avian influenza A (H7N9) virus. Nature 2013 Jul 3 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23823727
Belser JA et al. Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice. Nature 2013 Jul 10 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23842497
Watanabe T et al. Characterization of H7N9 influenza A viruses isolated from humans. Nature 2013 Jul 10; PMID: https://www.ncbi.nlm.nih.gov/pubmed/23842494
Zhu H et al. Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science 2013 Jul 12; 341:183 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23704376 <Internet> http://www.sciencemag.org/content/341/6142/183 - ↑ Qi X et al. Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: Epidemiological investigation. BMJ 2013 Aug 6; 347:f4752. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23920350 <Internet> http://www.bmj.com/content/347/bmj.f4752
Pavia AT Influenza A (H7N9): From anxiety to preparedness. Ann Intern Med 2013 Aug 6; 159:219 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23697995 <Internet> http://annals.org/article.aspx - ↑ 10.0 10.1 Li Q, Zhou L, Zhou M et al Epidemiology of Human Infections with Avian Influenza A(H7N9) Virus in China. N Engl J Med 2014; 370:520-532February 6, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23614499 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1304617
- ↑ 11.0 11.1 Centers for Disease Control & Prevention (CDC) Travel Advisory. Jan 16, 2017 Avian Flu (H7N9) in China https://wwwnc.cdc.gov/travel/notices/watch/avian-flu-h7n9
- ↑ 12.0 12.1 World Health Organization (WHO). Human infection with avian influenza A(H7N9) virus - China Disease outbreak news. 27 February 2017 http://www.who.int/csr/don/27-february-2017-ah7n9-china/en/
- ↑ 13.0 13.1 Iuliano AD, Jang Y, Jones J, et al. Increase in Human Infections with Avian Influenza A(H7N9) Virus During the Fifth Epidemic - China, October 2016 - February 2017. MMWR Morb Mortal Wkly Rep. ePub: 3 March 2017 https://www.cdc.gov/mmwr/volumes/66/wr/mm6609e2.htm
- ↑ Centers for Disease Control & Prevention (CDC) Avian Influenza A (H7N9) Virus https://www.cdc.gov/flu/avianflu/h7n9-virus.htm