neuraminidase inhibitor

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[1][2][3][4][5][6]

Indications

Benefit/risk

Adverse effects

Mechanism of action

Notes

  • oseltamivir & zanamivir are modestly effective for symptoms of influenza in otherwise healthy adults
  • when used prophylactically, they have no effect against in preventing influenza-like illness or asymptomatic influenza
  • the drugs reduce influenza's symptoms by about a day
  • benefit for very ill people in hospital is without supporting data[1]

More general terms

More specific terms

Additional terms

References

  1. ↑ 1.0 1.1 Jefferson T et al Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis BMJ 2009;339:b5106 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19995812 <Internet> http://www.bmj.com/cgi/content/full/339/dec07_2/b5106 http://dx.doi.org/10.1136/bmj.b5106
    Doshi P. Neuraminidase inhibitors - The story behind the Cochrane review. BMJ 2009 Dec 8; 339:b5164. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19995813 <Internet> http://dx.doi.org/10.1136/bmj.b5164
  2. ↑ 2.0 2.1 Muthuri SG et al. Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009-2010 influenza A (H1N1) pandemic: A systematic review and metaanalysis in hospitalized patients. J Infect Dis 2013 Feb 15; 207:553. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23204175
    Aoki FY and Hayden FG. The beneficial effects of neuraminidase inhibitor drug therapy on severe patient outcomes during the 2009-2010 influenza A virus subtype H1N1 pandemic. J Infect Dis 2013 Feb 15; 207:547. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23204176
  3. ↑ Jefferson T, Jones M, Doshi P, Del Mar C, Dooley L, Foxlee R. Neuraminidase inhibitors for preventing and treating influenza in healthy adults. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD001265 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20166059
    Jefferson T, Jones MA, Doshi P et al Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2014 Apr 10;4:CD008965 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24718923
  4. ↑ 4.0 4.1 Krumholz HM and Hines HH Neuraminidase inhibitors for influenza BMJ 2014;348:g2548 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24811413 <Internet> http://www.bmj.com/content/348/bmj.g2548
  5. ↑ The NNT: Neuraminidase Inhibitors Given for Influenza. http://www.thennt.com/nnt/neuraminidase-inhibitors-for-influenza/
  6. ↑ 6.0 6.1 Graner S et al Neuraminidase inhibitors during pregnancy and risk of adverse neonatal outcomes and congenital malformations: population based European register study. BMJ 2017;356:j629 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28246106 Free full text <Internet> http://www.bmj.com/content/356/bmj.j629
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