neuraminidase inhibitor

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Indications

Benefit/risk

Adverse effects

Mechanism of action

Notes

  • oseltamivir & zanamivir are modestly effective for symptoms of influenza in otherwise healthy adults
  • when used prophylactically, they have no effect against in preventing influenza-like illness or asymptomatic influenza
  • the drugs reduce influenza's symptoms by about a day
  • benefit for very ill people in hospital is without supporting data[1]

More general terms

More specific terms

Additional terms

References

  1. 1.0 1.1 Jefferson T et al Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis BMJ 2009;339:b5106 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19995812 <Internet> http://www.bmj.com/cgi/content/full/339/dec07_2/b5106 http://dx.doi.org/10.1136/bmj.b5106
    Doshi P. Neuraminidase inhibitors - The story behind the Cochrane review. BMJ 2009 Dec 8; 339:b5164. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19995813 <Internet> http://dx.doi.org/10.1136/bmj.b5164
  2. 2.0 2.1 Muthuri SG et al. Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009-2010 influenza A (H1N1) pandemic: A systematic review and metaanalysis in hospitalized patients. J Infect Dis 2013 Feb 15; 207:553. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23204175
    Aoki FY and Hayden FG. The beneficial effects of neuraminidase inhibitor drug therapy on severe patient outcomes during the 2009-2010 influenza A virus subtype H1N1 pandemic. J Infect Dis 2013 Feb 15; 207:547. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23204176
  3. Jefferson T, Jones M, Doshi P, Del Mar C, Dooley L, Foxlee R. Neuraminidase inhibitors for preventing and treating influenza in healthy adults. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD001265 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20166059
    Jefferson T, Jones MA, Doshi P et al Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2014 Apr 10;4:CD008965 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24718923
  4. 4.0 4.1 Krumholz HM and Hines HH Neuraminidase inhibitors for influenza BMJ 2014;348:g2548 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24811413 <Internet> http://www.bmj.com/content/348/bmj.g2548
  5. The NNT: Neuraminidase Inhibitors Given for Influenza. http://www.thennt.com/nnt/neuraminidase-inhibitors-for-influenza/
  6. 6.0 6.1 Graner S et al Neuraminidase inhibitors during pregnancy and risk of adverse neonatal outcomes and congenital malformations: population based European register study. BMJ 2017;356:j629 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28246106 Free full text <Internet> http://www.bmj.com/content/356/bmj.j629