metapneumovirus (MPV)
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Introduction
Etiologic agent of respiratory infections in children.
Epidemiology
- 80% of infections occur between February & May[6]
- high rate of infection in infants 0-5 months of age[6]
- infective for primates, but not birds[4]
- 6% of inpatients[8]
- 7% of outpatients
- 7% of emergency department patients
- 1% of asymptomatic controls[8]
Pathology
- produces pathology similar to respiratory syncytial virus (RSV)
- spectrum of disease from rhinitis to severe bronchitis & pneumonia
Genetics
- related to an avian virus Clinical manifestaions:
- 12% if children with lower respiratory tract infection
- 15% if children with upper respiratory tract infection
- 1% of asymptomatic children
Laboratory
- isolation from nasopharyngeal aspirates
- metapneumovirus antigen
- RT-PCR for metapneumovirus RNA
- metapneumovirus IgG in serum
- nearly 100% of adults have antibody to MPV
- see ARUP consult[7]
More general terms
References
- ↑ Journal Watch 21(13):108, 2001 van den Hoogen BG et al A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001 Jun;7(6):719-24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11385510
- ↑ van den Hoogen BG et al, Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis, 23(1 suppl): S25, 2004 (review) PMID: https://www.ncbi.nlm.nih.gov/pubmed/14730267
- ↑ van den Hoogen et al, Analysis of the genomic sequence of a human metapneumovirus. Virology 295:119-32, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12033771
- ↑ 4.0 4.1 Journal Watch 24(5):42, 2004 Williams JV et al Human metapneumovirus infection in young children hospitalized with acute respiratory tract disease: virologic and clinical features. N Engl J Med 350:443, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14749452
- ↑ Caracciolo S et al, Human metapneumovirus infection in young children hospitalized with acute respiratory tract disease: Virologic and clinical features. Pediatr Infect Dis J 2008, 27:406 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18382388
- ↑ 6.0 6.1 6.2 Williams JV et al. Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis 2010 Jun 15; 201:1890. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20446850
- ↑ 7.0 7.1 ARUP Consult: Metapneumovirus - hMPV The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/browse-all-topics
- ↑ 8.0 8.1 8.2 Edwards KM et al. Burden of human metapneumovirus infection in young children. N Engl J Med 2013 Feb 14; 368:633. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23406028 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1204630