HIV1/AIDS-associated malignancy
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Pathology
3 cancers are considered AIDS-defining conditions:
Overall, men & women with AIDS have a 2.5-fold increase for developing non AIDS-defining malignancies.
Risk of cancer increases with degree of immunosuppression:
Risk of other cancers increased with AIDS, but NOT with degree of immunosuppression.
- systemic high-grade lymphoma
- primary central nervous system lymphoma
- anogenital squamous cell cancer
- anal cancer
Risk of breast cancer & colon cancers NOT increased among AIDS patients
Reference[2] suggests younger age distribution of HIV patients relative to general population skews age distribution of non- AIDS-defining cancers & that perhaps HIV dose not increase risk of non AIDS-defining cancers
case report of malignant transformation of H nana invading human host as metastatic cancer in an HIV1 infected patient[4]
Management
- Kaposi sarcoma, non-Hodgkin's lymphoma, & lung cancer may be targets for early identification in patients with HIV1 infection[3]
More general terms
Additional terms
References
- ↑ Journal Watch 21(10):80, 2001 Frisch et al, JAMA 285:1736, 2001
- ↑ 2.0 2.1 Shiels MS et al. Age at cancer diagnosis among persons with AIDS in the United States. Ann Intern Med 2010 Oct 5; 153:452. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20921544
- ↑ 3.0 3.1 Silverberg MJ et al. Cumulative incidence of cancer among persons with HIV in North America: A cohort study. Ann Intern Med 2015 Oct 6; 163:507 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26436616 <Internet> http://annals.org/article.aspx?articleid=2450214
- ↑ 4.0 4.1 Muehlenbachs A et al Malignant Transformation of Hymenolepis nana in a Human Host. N Engl J Med 2015; 373:1845-1852. November 5, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26535513 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1505892
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015
- ↑ National Cancer Institute HIV Infection and Cancer Risk https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/hiv-fact-sheet