esmolol (Brevibloc)

From Aaushi
Jump to navigation Jump to search

Introduction

Tradename: Brevibloc.

Indications

Dosage

  • 5 g in 500 mL (10 mg/mL)
  • loading dose 500 ug/kg/min IV over 1 min
  • IV @ 50-200 ug/kg/min
  • 70 kg: 40 mL/hr = 100 ug/kg/min

Injection: 250 mg/mL (10 mL).

Pharmacokinetics

elimination via plasma

1/2life = 9 minutes

Adverse effects

Drug interactions

Mechanism of action

  • short-acting, selective beta-1 antagonist
  • beta-1 selectivity is diminished at high doses (> 300 ug/kg/min)

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. 4.0 4.1 4.2 Deprecated Reference

Database