esmolol (Brevibloc)

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Introduction

Tradename: Brevibloc.

Indications

Dosage

  • 5 g in 500 mL (10 mg/mL)
  • loading dose 500 ug/kg/min IV over 1 min
  • IV @ 50-200 ug/kg/min
  • 70 kg: 40 mL/hr = 100 ug/kg/min

Injection: 250 mg/mL (10 mL).

Pharmacokinetics

elimination via plasma

1/2life = 9 minutes

Adverse effects

Drug interactions

Mechanism of action

  • short-acting, selective beta-1 antagonist
  • beta-1 selectivity is diminished at high doses (> 300 ug/kg/min)

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Jump up to: 4.0 4.1 4.2 Deprecated Reference

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