bumetanide (Bumex)

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Introduction

Tradename: Bumex.

Indications

Dosage

Tabs: 0.5, 1, 2 mg.

1 mg of bumetanide is roughly equipotent to 40 mg of furosemide.

Pharmacokinetics

  • onset of action:
    • within 30-60 minutes after oral administration
    • within a few minutes after IV administration
  • duration of action
    • 4 hours with usual doses
    • 6 hours with higher doses

elimination via kidney

Adverse effects

Drug interactions

Mechanism of action

acts at loop of Henle

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. 3.0 3.1 Taubes A, Nova P, Zalocusky KA et al Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease. Nat Aging 2021. 1, 932-947 Not indexed in PubMed https://www.nature.com/articles/s43587-021-00122-7
  4. Department of Veterans Affairs, VA National Formulary

Database