torsemide (Demadex)

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Introduction

Tradename: Demadex.

Indications

* torsemide is no better than furosemide in patients hospitalized with heart failure[4]

* do not change loop diuretic to thiazide diuretic for hyperkalemia in patients with systolic heart failure

Contraindications

pregnancy category = b

safety in lactation = ?

Dosage

Tabs: 5, 10, 20 mg, 100 mg.

Injection: 10 mg/mL (2 mL, 5 mL)

* 10-20 mg of torsemide is approximately equivalent to: furosemide 40 mg, bumetanide 1 mg

Pharmacokinetics

elimination via liver

elimination via kidney

Adverse effects

Overdose:

Drug interactions

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  3. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
  4. Jump up to: 4.0 4.1 Mentz RJ, Anstrom KJ, Eisenstein EL et al Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure. The TRANSFORM-HF Randomized Clinical Trial. JAMA. 2023;329(3):214-223 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36648467 https://jamanetwork.com/journals/jama/fullarticle/2800428
  5. NEJM Knowledge+

Database