meclofenamate (Meclomen)

Introduction

Tradenames: Meclomen {meclofenamate] & Ponstel {meclofenamic acid}.

Indications

• temporary relief of minor aches, pains, fever & inflammation
• primary dysmenorrhea
  • menorrhagia

Dosage

• 50 mg PO TID/QID, max 300 mg/day {meclofenamate}
• 250 mg PO QID {meclofenamic acid}.

Tabs: 50, 100 mg {meclofenamate} 250 mg {meclofenamic acid}.

Pharmacokinetics

• duration of action: 2-4 hours

elimination via liver

Adverse effects

• common (> 10%)
  • rash, dizziness, abdominal cramps, heartburn, indigestion, nausea
• less common (1-10%)
  • itching, ringing in ears, fluid retention, headache, nervousness, vomiting
• uncommon (< 1%)
  • congestive heart failure, hypertension, arrhythmia, epistaxis, confusion, hallucinations, aseptic meningitis, depression, peripheral neuropathy, urticaria, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, gastritis, GI ulceration, cystitis, agranulocytosis, anemia, hemolytic anemia, bone marrow suppression, leukopenia, thrombocytopenia, hepatitis, angioedema, allergic rhinitis, toxic amblyopia, blurred vision, conjunctivitis, dry eyes, decreased hearing, polyuria, shortness of breath, olydipsia, tachycardia, hot flashes, drowsiness, insomnia, acute renal failure

• drug adverse effects of NSAIDs

Laboratory

• specimen: plasma
• methods: HPLC, GC

More general terms

• non-steroidal anti-inflammatory agent (NSAID)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4037
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4036
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=22881
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282369
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4038