ketoprofen (Orudis Oruvail)
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Introduction
Tradename: Orudis, Oruvail (sustained-release).
Dosage
- 50-75 mg PO TID
- 200 mg PO QD (sustained release)
Tabs: 25, 50, 75 mg.
Sustained-release: (Oruvail) 200 mg
Adverse effects
- dyspepsia
- peptic ulceration
- gastrointestinal bleeding
- headache
- insomnia
- anxiety
- thrombocytopenia
- anemia
- agranulocytosis
- rash
- edema
- nephrotoxicity (rare)
- hepatotoxicity (rare)
Drug interactions
- salicylates
- may divert metabolism to non-conjugated metabolites
- displace ketoprofen from plasma protein binding sites
- probenecid
- may inhibit conjugation of ketoprofen
- inhibits renal excretion of ketoprofen conjugates
- ketoprofen may inhibit renal excretion of:
- drug interaction(s) of cholinesterase inhibitors with NSAIDs
- drug interaction(s) of lithium carbonate with NSAIDs
- drug interaction(s) of NSAIDs with oral contraceptive
- drug interaction(s) of NSAIDs with SSRIs
- drug interaction(s) of NSAIDs with antidepressants
- drug interaction(s) of aspirin with NSAIDs
- drug interaction(s) of apixaban with NSAIDs
- drug interaction(s) of warfarin with NSAIDs
- drug interaction(s) of NSAIDs with beta blockers
- drug interaction(s) of NSAIDs with ARBs
- drug interaction(s) of NSAIDs with aldosterone antagonis
- drug interaction(s) of NSAIDs with glucocorticoid
- drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
- drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
- drug interaction(s) of NSAIDs with ACE inhibitors
- drug interaction(s) of NSAIDs & antihypertensives
- drug interaction(s) of NSAIDs & loop diuretics
- drug interaction(s) of NSAIDs & aspirin