mitoxantrone (Novantrone, Mitozantrone)

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Indications

Contraindications

pregnancy category = d

Dosage

Stability:

  • incompatible with heparin
  • after penetration of stopper, stable for 7 days at room temperature or 14 days refrigerated

Injection: 2 mg/mL (10 mL, 12.5 mL, 15 mL).

Pharmacokinetics

elimination via liver

1/2life = 1 hour

elimination by hemodialysis = -

Monitor

Adverse effects

Toxicity: no known antidote

Test interactions

increases serum K+

Mechanism of action

More general terms

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Jump up to: 3.0 3.1 3.2 Prescriber's Letter 7(12):71 2000
  4. Jump up to: 4.0 4.1 4.2 FDA MedWatch http://www.fda.gov/medwatch/SAFETY/2005/safety05.htm#Novantrone
  5. Jump up to: 5.0 5.1 5.2 FDA MedWatch http://www.fda.gov/medwatch/safety/2008/safety08.htm#Mitoxantrone
  6. Jump up to: 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 16, 17. American College of Physicians, Philadelphia 2012, 2015
  7. Jump up to: 7.0 7.1 Deprecated Reference

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