transcription factor PML; tripartite motif-containing protein 19; RING finger protein 71 (PML, MYL, RNF71, TRIM19)

Function

• probable transcription factor
• may play role in recruitment of ELF4 into PML nuclear bodies
• interacts with SIRT1, TOPBP1, TRIM27 & TRIM69
• interacts with the C-terminus of ELF4.
• interacts with Lassa virus Z protein & rabies virus phosphoprotein (putative)
• ubiquitinated; mediated by SIAH1 or SIAH2 & leading to its subsequent proteasomal degradation
• sumoylation on all three sites is required for nuclear body formation
• sumoylation on Lys-160 is a prerequisite for sumoylation on Lys-65
• the PML-RARA fusion protein is not sumoylated

Structure

• contains 2 B box-type Zn+2 fingers contains 1 RING-type Zn+2 finger

Compartment

• nucleus, nucleoplasm, cytoplasm
• sumoylated forms localize to the PML nuclear bodies
• the B1 box & the RING finger are also required for this nuclear localization
• isoforms lacking a nuclear localization signal are cytoplasmic

Alternative splicing

• named isoforms=5
• additional isoforms seem to exist

Pathology

• chromosomal translocation t(15;17)(q21;q21) involving PML with RARA may be a cause of acute promyelocytic leukemia; the PML breakpoints (type A & type B) lie on either side of an alternatively spliced exon
• autoantibody ? (see Laboratory)

Laboratory

• PML antibody in serum

More general terms

• DNA-binding protein
• transcription factor (TF)
• proto oncogene protein
• ring finger protein

More specific terms

• transcription factor PML-1
• transcription factor PML-2
• transcription factor PML-3
• transcription factor PML-3B
• transcription factor PML-X or My1 protein

Additional terms

• AML-M3; acute promyelocytic leukemia

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5371
• UniProt: http://www.uniprot.org/uniprot/P29590.html
• OMIM: https://mirror.omim.org/entry/102578
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5371