pleckstrin homology domain-containing family O member 1 (casein kinase 2-interacting protein 1, CK2-interacting protein-1, CKIP-1, c-Jun-binding protein, JBP, PLEKHO1, CKIP1, OC120, HQ0024c)

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Function

role in the regulation of the actin cytoskeleton through its interactions with actin capping protein
may function to target CK2 & ATM to the plasma membrane thus serving as an adapter to facilitate the phosphorylation of actin capping protein by protein kinase 2 (CK2)
appears to inhibit tumor cell growth by inhibiting AKT-mediated cell-survival
implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) & the promotion of apoptosis induced by tumor necrosis factor TNF
heterodimer or homodimer
interacts with CK2 & actin capping subunits (capping protein CP-alpha & CP-beta)
CKIP1 & CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments
interacts with ATM, IFP35, JUN, JUND, NMI & PI3K
C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage

contains 1 PH domain

membrane, nucleus
predominantly localized to the plasma membrane
in C2C12 cells, with the absence of growth factor, it is found in the nucleus
rapidly translocates to the plasma membrane after insulin stimulation
in response to TNF, translocates from the plasma membrane to the cytoplasm & then to the nucleus accompanied by cleavage by caspase-3
subcellular location is highly dependent on cell type
found exclusively at plasma membrane, in some cells

expressed in skeletal muscle & heart > kidney, liver, brain & placenta > pancreas & lung
up-regulated by IFN-gamma & IL2 or in C2C12 cells