programmed cell death protein 10; cerebral cavernous malformations 3 protein; TF-1 cell apoptosis-related protein 15 (PDCD10, CCM3, TFAR15)

Function

• promotes cell proliferation
• modulates apoptotic pathways
• increases mitogen-activated protein kinase activity & MST4 activity
• important for cell migration, & for normal structure & assembly of the Golgi complex
• important for KDR/VEGFR2 signaling
  • increases stability of KDR/VEGFR2 & prevents its breakdown
• required for normal cardiovascular development
• required for normal angiogenesis, vasculogenesis & hematopoiesis during embryonic development (putative)
• interacts (via C-terminus) with CCM2 & PXN
• interacts (via N-terminus) with MST4, STK24 & STK25
• interacts with GOLGA2
• identified in a complex with CCM1 & CCM2
• interacts with KDR/VEGFR2
• interaction with KDR/VEGFR2 is enhanced by stimulation with VEGFA (putative)

Structure

• homodimer
• belongs to the PDCD10 family

Compartment

• cytoplasm, Golgi membrane
• plasma membrane, cytoplasmic side
• partially co-localizes with endogenous PXN at the leading edges of migrating cells

Expression

ubiquitous

Pathology

• defects in PDCD10 are the cause of cerebral cavernous malformations type 3

More general terms

• RNA-binding protein
• nuclear protein

Additional terms

• apoptosis
• programmed cell death protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11235
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11235
• OMIM: https://mirror.omim.org/entry/603285
• OMIM: https://mirror.omim.org/entry/609118
• UniProt: http://www.uniprot.org/uniprot/Q9BUL8.html