serine/threonine protein kinase 25; ste20-like kinase; sterile 20/oxidant stress-response kinase 1; SOK-1; ste20/oxidant stress response kinase 1 (STK25, SOK1, YSK1)

Function

• oxidant stress-activated serine/threonine kinase
• may play a role in the response to environmental stress
• targets to the Golgi where it appears to regulate protein transport, cell adhesion, & polarity complexes important for cell migration
• interaction with Golgi matrix protein GOLGA2
• leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation
• the C-terminal non-catalytic region inhibits kinase activity
• phosphorylated upon DNA damage, probably by ATM or ATR

Cofactor: Mg+2

Structure

• homodimer
• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm
• Golgi
• localizes to the Golgi

Expression

• ubiquitously expressed
• highest levels are found in testis, large intestine, brain & stomach followed by heart & lung

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10494
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10494
• OMIM: https://mirror.omim.org/entry/602255
• UniProt: http://www.uniprot.org/uniprot/O00506.html