serine/threonine-protein kinase MST4; mammalian STE20-like protein kinase 4; MST-4; Mst3 & SOK1-related kinase; STE20-like kinase MST4; serine/threonine protein kinase MASK (MST4, MASK)

Function

• may regulate of cell growth
• pro-apoptotic
• interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation
• may also be activated by C- terminal cleavage

Cofactor: Mg+2 (putative)

Structure

• nhomodimer
• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm, Golgi membrane
• peripheral membrane protein, cytoplasmic side
• localizes to the Golgi

Alternative splicing

named isoforms=3

More general terms

• serine/threonine kinase
• oligomerizing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51765
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51765
• OMIM: https://mirror.omim.org/entry/300547
• UniProt: http://www.uniprot.org/uniprot/Q9P289.html