anatomic predilection of Alzheimer's pathology

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Pathology

Neurofibrillary lesions* occur prior to beta-amyloid lesions in most patients with AD[9]

Predilection of neurofibrillary lesions*

* neuropil threads & neurofibrillary tangles, see Braak staging

Predilection of beta-amyloid lesions

Areas relatively spared:

distribution of amyloid pathology in AD differs from that of traumatic brain injury[11]

Braak staging:

Neuronal types affected in AD

More general terms

Additional terms

References

  1. Greenfield's Neuropathology, 5th ed., 1992
  2. Arendt T. Neurodegeneration and plasticity. Int J Dev Neurosci. 2004 Nov;22(7):507-14. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15465280
  3. 3.0 3.1 3.2 Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl). 1991;82(4):239-59. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1759558
  4. 4.0 4.1 Mesulam M, Shaw P, Mash D, Weintraub S. Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol. 2004 Jun;55(6):815-28. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15174015
  5. 5.0 5.1 Braak H, Rub U, Schultz C, Del Tredici K. Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases. J Alzheimers Dis. 2006;9(3 Suppl):35-44. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16914843
  6. 6.0 6.1 Christen-Zaech S, Kraftsik R, Pillevuit O, Kiraly M, Martins R, Khalili K, Miklossy J. Early olfactory involvement in Alzheimer's disease. Can J Neurol Sci. 2003 Feb;30(1):20-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12619779
  7. 7.0 7.1 Attems J and Jellinger KA, Olfactory tau pathology in Alzheimer disease and mild cognitive impairment. Clin Neuropathol. 2006, 25:265 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17140156
  8. 8.0 8.1 8.2 Esiri MM and Chance SA Vulnerability of Alzheimer's pathology in the neocortex: the roles of plasticity and columnar organization. J Alzheimer's disease 2006, 9(3 Suppl):79 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16914847
  9. 9.0 9.1 9.2 9.3 9.4 Braak H and Tredici KD Alzheimer's pathogenesis: is there neuron-to-neuron propagation? Acta Neuropathol (2011) 121:589-595 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21516512
  10. 10.0 10.1 Kunz L et al. Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease. Science 2015 Oct 23; 350:430. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26494756
  11. 11.0 11.1 Anderson P Amyloid Pattern in TBI Different Than in Alzheimer's Medscaope. February 05, 2016 http://www.medscape.com/viewarticle/858463
  12. 12.0 12.1 Pascoal TA, Benedet AL, Ashton NJ et al. Microglial activation and tau propagate jointly across Braak stages. Nat Med 2021. August 21 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34446931 https://www.nature.com/articles/s41591-021-01456-w