FK506-binding protein 5 (51 kD FK506-binding protein, 54 kD progesterone receptor-associated immunophilin, FKBP54, FF1 antigen, HSP90-binding immunophilin, androgen-regulated protein 6, FKBP5)

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Function

peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

Compartment

cytoplasm. nucleus

Expression

  • widely expressed
  • enriched in testis compared to other tissues
  • induced by androgen

Pathology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q13451.html
  2. 2.0 2.1 2.2 2.3 Zannas AS, Jia M, Hafner K et al. Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa-B driven inflammation and cardiovascular risk. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11370-11379. PMID: https://www.ncbi.nlm.nih.gov/pubmed/31113877 Free PMC Article https://www.pnas.org/content/116/23/11370

Database