prostaglandin E synthase 3; cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; progesterone receptor complex p23; telomerase-binding protein p23 (PTGES3, P23, TEBP)

Function

• molecular chaperone that localizes to genomic response elements in a hormone-dependent manner & disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes
• lipid metabolism; prostaglandin biosynthesis
• binds to the progesterone receptor
• interacts with TERT; interaction, together with HSP90A1, is required for correct assembly & stabilization of the telomerase holoenzyme complex

Kinetic parameters:

• KM=14 uM for PGH2
• Vmax=190 nmol/min/mg enzyme toward PGH2

Structure

• belongs to the p23/wos2 family
• contains 1 CS domain

Compartment

cytoplasm

More general terms

• prostaglandin [PG] synthase
• chaperonin; chaperone
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10728
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10728
• OMIM: https://mirror.omim.org/entry/607061
• UniProt: http://www.uniprot.org/uniprot/Q15185.html