Ancient ubiquitous protein 1 (AUP1)

Function

• may play a role in translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm & their degradation by the proteasome
• identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E & AUP1
• interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV & ITGAM

Structure

• belongs to the AUP1 family
• contains 1 CUE domain

Compartment

• endoplasmic reticulum membrane
• single-pass type 3 membrane protein; cytoplasmic side

Alternative splicing

named isoforms=3; long, short

Expression

• detected in blood platelets & leukocytes (at protein level)
• ubiquitous
• highly expressed in placenta, liver, kidney, skeletal muscle, heart & brain

More general terms

• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=550
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:550
• OMIM: https://mirror.omim.org/entry/602434
• UniProt: http://www.uniprot.org/uniprot/Q9Y679.html