FAS-associated factor 2; UBX domain-containing protein 3B; UBX domain-containing protein 8; protein ETEA (FAF2, ETEA, KIAA0887, UBXD8, UBXN3B)

Function

• may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm & their degradation by the proteasome
• identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E & AUP1. interacts with YOD1

Structure

• contains 1 UBA domain
• contains 1 UBX domain

Compartment

cytoplasm, lipid droplet, endoplasmic reticulum

Expression

broadly expressed, with highest levels in brain

Pathology

• up-regulated in T-cells & eosinophils from patients with atopic dermatitis

More general terms

• UBX domain-containing protein (UBXD)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23197
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23197
• UniProt: http://www.uniprot.org/uniprot/Q96CS3.html