protein sel-1 homolog 1; suppressor of lin-12-like protein 1; sel-1L (SEL1L, TSA305, UNQ128/PRO1063)

Function

• probable role in notch signaling
• may play role in endoplasmic reticulum quality control (ERQC) (ER-associated degradation, ERAD)
• involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins
• part of a complex containing SEL1L, SYVN1 & DERL2
• may form a complex with ERLEC1, HSPA5, OS9, & SYVN1
• interacts with FOXRED2

Structure

• N-glycosylated
• belongs to the sel-1 family
• contains 1 fibronectin type-II domain
• contains 11 sel1-like repeats

Compartment

• endoplasmic reticulum membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

highly expressed in pancreas

More general terms

• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6400
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6400
• OMIM: https://mirror.omim.org/entry/602329
• UniProt: http://www.uniprot.org/uniprot/Q9UBV2.html