derlin-2 (degradation in endoplasmic reticulum protein 2, Der1-like protein 2, DERtrin-2, DERL2, F-LANa, F-LAN-1, DERL2, DER2, FLANA, CGI-101, SBBI53)

Function

• endoplasmic reticulum-associated degradation
  • misfolded lumenal glycoproteins, but NOT that of misfolded non-glycoproteins
• forms channel that allows the retrotranslocation of misfolded glycoproteins into cytosol where they are ubiquitinated & degraded by the proteasome (putative)
• mediates interaction between VCP & the degradation substrate
• forms homo- & heterooligomers with DERL2 & DERL1
• interacts with SELS, VCP & EDEM1
• up-regulated in the unfolded protein response
  • via the ERN1-XBP1 pathway

Compartment

endoplasmic reticulum membrane

Expression

ubiquitous

Pathology

• overexpressed in hepatocarcinomas

More general terms

• derlin

Database

• UniProt: http://www.uniprot.org/uniprot/Q9GZP9.html