ER degradation-enhancing alpha-mannosidase-like 1 (EDEM1, EDEM, KIAA0212)

Function

• extracts misfolded glycoproteins from calnexin cycle
• role in endoplasmic reticulum-associated degradation of glycoprotein
• targets misfolded glycoproteins for degradation (N-glycan- dependent)
• lacks mannosidase activity
• interacts with DERL2 & DERL3

Structure

• belongs to the glycosyl hydrolase 47 family

Compartment

edoplasmic reticulum membrane

More general terms

• membrane protein
• glycoprotein

Additional terms

• ER degradation-enhancing alpha-mannosidase-like

Database

• OMIM: https://mirror.omim.org/entry/607673
• UniProt: http://www.uniprot.org/uniprot/Q92611.html