CD49b (integrin alpha-2, VLA-2 alpha chain or platelet membrane glycoprotein IA, ITGA2)
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Function
- heterodimer with integrin beta-1 (integrin alpha-2/beta-1)
- interacts with HPS5
Structure
- the integrin I-domain (insert) is a VWFA domain
- integrins with I-domains do not undergo protease cleavage
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
- contains 1 VWFA domain
Compartment
membrane
Pathology
Laboratory
More general terms
Component of
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 769
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3673
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ITGA2
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/itga2/
- ↑ UniProt http://www.uniprot.org/uniprot/P17301.html