very late antigen 2 (VLA-2, integrin alpha-2/beta-1)

Function

• integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin & E-cadherin
• recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen
• responsible for adhesion of platelets & other cells to collagens, modulation of collagen & collagenase gene expression, force generation & organization of newly synthesized extracellular matrix

Subunits

integrin alpha-2, integrin beta-1

Compartment

membrane

Pathology

• putative receptor for echovirus-1

More general terms

• CD49 or Very Late Antigen (VLA)

Additional terms

• collagen
• echovirus
• fibronectin; FN; cold-insoluble globulin; CIG; contains: anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3 (FN1, FN)
• laminin